Argentina, Brazil and Egypt are among the nations listed on the "UK" Government for travel to England, which means it will take a ten-day period of hotel divisions before players can return to their clubs.
That would mean Mohamed Salah will not be able to play in Egypt's World Cup qualifiers in Cairo and Angola on September 2 - and the Egyptian FA says Liverpool have already informed them that Salah will not be available - although the player will be free to travel to Gabon three days later.
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Unless the problems to be resolved can be resolved, a number of Premier League players may not be available for next month's international matches, as will PSG stars Lionel Messi and Neymar.
Return to England from 'red list'
The Government says those returning to England from a country on their "red" list must be separated for 10 full days in a detached hotel and have a coronavirus test before or before day 2 and day or after 8 days of separation.
Chile, Colombia, Mexico, Turkey and Uruguay are some of the countries on the "red" Government list.
Brazil will host Argentina in the World Cup Qualifier in Maracana on September 5, and the current ECA doubts could deter many players from that match and many other games in South America.
Eight Premier League players have been selected for the upcoming Brazil squad, while three Liverpool players Alisson Becker, Fabinho and Roberto Firmino have joined Ederson and Gabriel Jesus (both Manchester City), Thiago Silva (Chelsea), Fred (Manchester United), Richarlison (Everton), Raphinha (Leeds United).
Aston Villa and Argentina goalkeeper Emiliano Martinez, who started in the Copa America final 1-0 against Brazil last month, will also be banned from playing in his national qualifiers.
Paris Saint-Germain are also members of the ECA, meaning Messi, Neymar, and Marquinhos and Angel Di Maria could no longer miss Argentina and Brazil among France's "red" list - the French government is also using a light traffic system.
Despite negotiations between the Premier League and DCMS, it is understood that no agreement has been reached regarding the release of the players.
Sky Sports News understands the Premier League and the FA, and other ECA members, hope to find a solution, clubs willing to release players if the rules of separation are proposed while FIFA hopes an agreement like the one used during the Euro can be reached as it affects very few players - less than 100 in England.
Earlier this year, FIFA announced that exemptions that would allow clubs not to release international players would expire, meaning Premier League clubs could face penalties if they let players join their national teams.
The government has denied release to British and Irish Lions players when they returned from South Africa earlier this month.
It is unknown at this time what he will do after leaving the post.